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About Hua Medicine

Collaborative Innovation

Hua Medicine is an innovative drug development and commercialization company based in Shanghai, China. Hua Medicine focused on developing novel therapies for patients worldwide with unmet medical needs. Based on global resources, Hua Medicine teams up with global high-caliber people to develop breakthrough technologies and products, which contribute a global innovation in diabetes care.

2011
Established
70%
R&D Team
100+
Clinical Center
2011
Established
70%
R&D Team
100+
Clinical Center
Scientific R&D

Research Area

Glucokinase Activator(GKA) --- Dorzagliatin(HMS5552)is a first-in-class oral drug for the treatment of type 2 diabetes that under developed by Hua Medicine. Dorzagliatin has brand new mechanism and structure.
mGluR5 negative allosteric modulators (NAM) as potential novel treatment for levodopa-induced dyskinesia in Parkinson’s disease (PD-LID) and plan to initiate clinical studies in the near future.
Glucokinase Activator(GKA) --- Dorzagliatin(HMS5552)is a first-in-class oral drug for the treatment of type 2 diabetes that under developed by Hua Medicine. Dorzagliatin has brand new mechanism and structure.
mGluR5 negative allosteric modulators (NAM) as potential novel treatment for levodopa-induced dyskinesia in Parkinson’s disease (PD-LID) and plan to initiate clinical studies in the near future.
Type 2 Diabetes Therapy

The Concept of Glucose Homeostasis

&
In Healthy Humans

Glucose concentrations for healthy individuals are maintained within a narrow range of 4-6.5mM --- glucose homeostasis, and regulated by various pathways. As the glucose sensor, glucokinase (GK) senses changes in glucose levels, which is essential for maintaining whole-body glucose homeostasis.

&
In Patients with Type 2 Diabetes

Impaired GK activity and function in T2D patients results in defects in glucose sensing, leading to disrupted glucose homeostasis.

&
Glucokinase Activator (GKA) Restores

A GKA can repair defective GK function and restore glucose homeostasis.

&
In Healthy Humans

Glucose concentrations for healthy individuals are maintained within a narrow range of 4-6.5mM --- glucose homeostasis, and regulated by various pathways. As the glucose sensor, glucokinase (GK) senses changes in glucose levels, which is essential for maintaining whole-body glucose homeostasis.

&
In Patients with Type 2 Diabetes

Impaired GK activity and function in T2D patients results in defects in glucose sensing, leading to disrupted glucose homeostasis.

&
Glucokinase Activator (GKA) Restores

A GKA can repair defective GK function and restore glucose homeostasis.

GK
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